![]() ![]() CT scan measures of emphysema and gas trapping were not predictive of 6MWD after adjustment for other phenotypic characteristics.Ībstract = "Background: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV1. Conclusions: In this large cohort of smokers in a given spirometric stage, phenotypic characteristics were only modestly predictive of 6MWD. In a given spirometric group, only 16% to 27% of the variance in 6MWD could be explained by age, male sex, Caucasian race, and lower BMI as significant predictors of higher 6MWD. ![]() However, in a given spirometric group, after adjustment for age, sex, race, and BMI, neither % emphysema nor % gas trapping, or their interactions with FEV 1% predicted, remained a significant 6MWD predictor. Higher % emphysema and % gas trapping predicted lower 6MWD (P <.001). Fifty-six percent had spirometrically defined COPD, with 9.3%, 23.4%, 15.0%, and 8.3% in GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I to IV, respectively. Participant age was 61 ± 9 years 51% were men 76% were non-Hispanic Caucasians, and 24% were African Americans. Results: Data of the first 2,500 participants of the COPDGene cohort were analyzed. We defined % emphysema as the percentage of lung voxels, < -950 Hounsfield units on the inspiratory scan and % gas trapping as the percentage of lung voxels, < -856 Hounsfield units on the expiratory scan. Phenotyping measures include postbronchodilator FEV 1 % predicted and inspiratory and expiratory CT lung scans. Methods: COPDGene recruits non-Hispanic Caucasian and African American current and ex-smokers. We determined whether other phenotypic characteristics, including CT scan measures, are independent predictors of 6-min walk distance (6MWD) in the COPDGene cohort. Van Beek, Brad Thompson, Fernando Martinez, Mei Lan Han, Christine Wendt, Frank Sciurba, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Antonio Anzueto, Sandra Adams, Carlos Orozco, Mario Ruiz, Edwin Silverman, Elizabeth Regan, Sarah Moyle, Lori Stepp, Rochelle Lantz, Terri Beaty, Barbara Klanderman, Nan Laird, Christoph Lange, Michael Cho, Stephanie Santorico, John Hokanson, Jacqueline Hetmanski, Tanda Murray, John Reilly, Harvey Coxson, Philip Judy, Eric Hoffman, Raul San Jose Estepar, James Ross, Rebecca Leek, Jordan Zach, Alex Kluiber, Jered Sieren, Heather Baumhauer, Verity McArthur, Demitry Kazlouski, Deanna Richert, Tom Gethin-Jones, Andrew Allen, Tanya Mann, Anastasia Rodionova, Douglas Stinson, Robert Jensen, Homayoon Farzadegan, Stacey Meyerer, Shivam Chandan, Samantha Bragan, James Murphy, Douglas Everett, Carla Wilson, Ruthie Knowles, Amber Powell, Joe Piccoli, Maura Robinson, Margaret Forbes, Martina Wamboldt, Marci Sontag, Jennifer Black-Shinn, Gregory Kinney Show 108 others Show lessīackground: Exercise tolerance in COPD is only moderately well predicted by airflow obstruction assessed by FEV 1. James Mamary, Robert Steiner, Chandra Dass, William Bailey, Mark Dransfield, Hrudaya Nath, Joe Ramsdell, Paul Friedman, Dwight Look, Geoffrey McLennan, Edwin J.R. Budoff, Amir Sharafkhaneh, Hirani Kamal, Roham Darvishi, Dennis Niewoehner, Tadashi Allen, Quentin Anderson, Kathryn Rice, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Russell Bowler, Adam Friedlander, David Lynch, Joyce Schroeder, John Newell, Gerard Criner, Victor Kim, Nathaniel Marchetti, Aditi Satti, A. Page McAdams, Richard Rosiello, Timothy Bresnahan, Charlene McEvoy, Joseph Tashjian, Robert Wise, Nadia Hansel, Robert Brown, Gregory Diette, Hans Fischer, Matthew J. Graham Barr, Byron Thomashow, John Austin, Neil MacIntyre, Lacey Washington, H. Crapo, Richard Casaburi, Jeffrey Curtis, Ella Kazerooni, Nicola Hanania, Philip Alapat, Venkata Bandi, Kalpalatha Guntupalli, Elizabeth Guy, Antara Mallampalli, Charles Trinh, Hasan Al-Azzawi, Mustafa Atik, Dawn DeMeo, Craig Hersh, George Washko, Francine Jacobson R. ![]()
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